A US drone strike on Wednesday killed at least six militants in a Pakistani tribal region where Islamabad launched a full-scale military offensive last year, security officials said.

A US drone strike on Wednesday killed at least six militants in a Pakistani tribal region where Islamabad launched a full-scale military offensive last year, security officials said.

The strike targeted a Taliban compound in North Waziristan, one of seven semi-autonomous tribal districts that border Afghanistan and a hub for Al-Qaeda and Taliban militants since the early 2000s.

"A US drone fired two missiles at a compound and vehicle in Shawal area of North Waziristan, killing six terrorists," a senior security official told AFP, speaking on condition of anonymity.

Another security official confirmed the strike and casualties.