A large explosion has struck Venezuela’s largest oil refinery, killing 19 people and injuring a further 53.

A large explosion has struck Venezuela’s largest oil refinery, killing 19 people and injuring a further 53. The blast did significant damage to the plant as well as nearby houses and is thought to have been caused by a gas leak.

"There was a gas leak," Energy Minister Rafael Ramirez told state TV. "A cloud of gas exploded … it was a significant explosion, there is significant damage to infrastructure and houses opposite the refinery."

The Amuay refinery produces  955,000 barrels a day and is located on the Paragana Peninsular in the northwest Falcon province.

The explosion occurred at approximately 1:07am local time (6:07 GMT) on Saturday, producing a tremor that was felt in nearby communities, smashing windows and damaging buildings.

Local authorities have restricted access to the refinery and the surrounding area in response to the blaze.

Ivan Freites, secretary of the United Federation of Oil Workers told state news that at 12:30am local time (05:30 GMT) a propane-butane leak was reported at the plant.

“The senior staff at the plant said they had used foam to control the leak and eliminate the risk of a fire,” said Freites.

He added that the explosion could have been triggered by a problem with a gas valve that led to a pressure buildup.